Presets Section in Audiences
The "Presets" Tab purpose is helping you start configuring your audience faster. In this section, you select a pre-configured audience that fits your needs.
If you can not find a preconfigured audience that fits your needs, then you need to create an Audience in the "New Audience" section.
These instructions pertain to the new Audiences Interface. This applies to all experiences created after the new Legacy Audiences launch before September 16th, 2017.
Go here to find the documentation related to the legacy audiences interface.